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2^{16}x^{16}-\left(3y\right)^{8}
Expand \left(2x\right)^{16}.
65536x^{16}-\left(3y\right)^{8}
Calculate 2 to the power of 16 and get 65536.
65536x^{16}-3^{8}y^{8}
Expand \left(3y\right)^{8}.
65536x^{16}-6561y^{8}
Calculate 3 to the power of 8 and get 6561.
2^{16}x^{16}-\left(3y\right)^{8}
Expand \left(2x\right)^{16}.
65536x^{16}-\left(3y\right)^{8}
Calculate 2 to the power of 16 and get 65536.
65536x^{16}-3^{8}y^{8}
Expand \left(3y\right)^{8}.
65536x^{16}-6561y^{8}
Calculate 3 to the power of 8 and get 6561.