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4x^{2}-8x-2xy+2yx-4y-y^{2}-8x+16+4y
Apply the distributive property by multiplying each term of 2x+y-4 by each term of 2x-4-y.
4x^{2}-8x-4y-y^{2}-8x+16+4y
Combine -2xy and 2yx to get 0.
4x^{2}-16x-4y-y^{2}+16+4y
Combine -8x and -8x to get -16x.
4x^{2}-16x-y^{2}+16
Combine -4y and 4y to get 0.
4x^{2}-8x-2xy+2yx-4y-y^{2}-8x+16+4y
Apply the distributive property by multiplying each term of 2x+y-4 by each term of 2x-4-y.
4x^{2}-8x-4y-y^{2}-8x+16+4y
Combine -2xy and 2yx to get 0.
4x^{2}-16x-4y-y^{2}+16+4y
Combine -8x and -8x to get -16x.
4x^{2}-16x-y^{2}+16
Combine -4y and 4y to get 0.