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4x^{2}+12xy+9y^{2}-\left(4y-5x\right)^{2}
Use binomial theorem \left(a+b\right)^{2}=a^{2}+2ab+b^{2} to expand \left(2x+3y\right)^{2}.
4x^{2}+12xy+9y^{2}-\left(16y^{2}-40yx+25x^{2}\right)
Use binomial theorem \left(a-b\right)^{2}=a^{2}-2ab+b^{2} to expand \left(4y-5x\right)^{2}.
4x^{2}+12xy+9y^{2}-16y^{2}+40yx-25x^{2}
To find the opposite of 16y^{2}-40yx+25x^{2}, find the opposite of each term.
4x^{2}+12xy-7y^{2}+40yx-25x^{2}
Combine 9y^{2} and -16y^{2} to get -7y^{2}.
4x^{2}+52xy-7y^{2}-25x^{2}
Combine 12xy and 40yx to get 52xy.
-21x^{2}+52xy-7y^{2}
Combine 4x^{2} and -25x^{2} to get -21x^{2}.
4x^{2}+12xy+9y^{2}-\left(4y-5x\right)^{2}
Use binomial theorem \left(a+b\right)^{2}=a^{2}+2ab+b^{2} to expand \left(2x+3y\right)^{2}.
4x^{2}+12xy+9y^{2}-\left(16y^{2}-40yx+25x^{2}\right)
Use binomial theorem \left(a-b\right)^{2}=a^{2}-2ab+b^{2} to expand \left(4y-5x\right)^{2}.
4x^{2}+12xy+9y^{2}-16y^{2}+40yx-25x^{2}
To find the opposite of 16y^{2}-40yx+25x^{2}, find the opposite of each term.
4x^{2}+12xy-7y^{2}+40yx-25x^{2}
Combine 9y^{2} and -16y^{2} to get -7y^{2}.
4x^{2}+52xy-7y^{2}-25x^{2}
Combine 12xy and 40yx to get 52xy.
-21x^{2}+52xy-7y^{2}
Combine 4x^{2} and -25x^{2} to get -21x^{2}.