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2^{-2}+\left(-4\right)^{3}\times 16^{-2}
To raise a power to another power, multiply the exponents. Multiply \frac{1}{2} and -4 to get -2.
\frac{1}{4}+\left(-4\right)^{3}\times 16^{-2}
Calculate 2 to the power of -2 and get \frac{1}{4}.
\frac{1}{4}-64\times 16^{-2}
Calculate -4 to the power of 3 and get -64.
\frac{1}{4}-64\times \frac{1}{256}
Calculate 16 to the power of -2 and get \frac{1}{256}.
\frac{1}{4}-\frac{1}{4}
Multiply -64 and \frac{1}{256} to get -\frac{1}{4}.
0
Subtract \frac{1}{4} from \frac{1}{4} to get 0.