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Differentiate w.r.t. x
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\frac{16^{\frac{1}{4}}\left(x^{4}\right)^{\frac{1}{4}}\left(y^{5}\right)^{\frac{1}{4}}}{\left(4x^{\frac{5}{8}}y^{\frac{1}{8}}\right)^{-2}}
Expand \left(16x^{4}y^{5}\right)^{\frac{1}{4}}.
\frac{16^{\frac{1}{4}}x^{1}\left(y^{5}\right)^{\frac{1}{4}}}{\left(4x^{\frac{5}{8}}y^{\frac{1}{8}}\right)^{-2}}
To raise a power to another power, multiply the exponents. Multiply 4 and \frac{1}{4} to get 1.
\frac{16^{\frac{1}{4}}x^{1}y^{\frac{5}{4}}}{\left(4x^{\frac{5}{8}}y^{\frac{1}{8}}\right)^{-2}}
To raise a power to another power, multiply the exponents. Multiply 5 and \frac{1}{4} to get \frac{5}{4}.
\frac{2x^{1}y^{\frac{5}{4}}}{\left(4x^{\frac{5}{8}}y^{\frac{1}{8}}\right)^{-2}}
Calculate 16 to the power of \frac{1}{4} and get 2.
\frac{2xy^{\frac{5}{4}}}{\left(4x^{\frac{5}{8}}y^{\frac{1}{8}}\right)^{-2}}
Calculate x to the power of 1 and get x.
\frac{2xy^{\frac{5}{4}}}{4^{-2}\left(x^{\frac{5}{8}}\right)^{-2}\left(y^{\frac{1}{8}}\right)^{-2}}
Expand \left(4x^{\frac{5}{8}}y^{\frac{1}{8}}\right)^{-2}.
\frac{2xy^{\frac{5}{4}}}{4^{-2}x^{-\frac{5}{4}}\left(y^{\frac{1}{8}}\right)^{-2}}
To raise a power to another power, multiply the exponents. Multiply \frac{5}{8} and -2 to get -\frac{5}{4}.
\frac{2xy^{\frac{5}{4}}}{4^{-2}x^{-\frac{5}{4}}y^{-\frac{1}{4}}}
To raise a power to another power, multiply the exponents. Multiply \frac{1}{8} and -2 to get -\frac{1}{4}.
\frac{2xy^{\frac{5}{4}}}{\frac{1}{16}x^{-\frac{5}{4}}y^{-\frac{1}{4}}}
Calculate 4 to the power of -2 and get \frac{1}{16}.
\frac{2y^{\frac{3}{2}}x^{\frac{9}{4}}}{\frac{1}{16}}
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
2y^{\frac{3}{2}}x^{\frac{9}{4}}\times 16
Divide 2y^{\frac{3}{2}}x^{\frac{9}{4}} by \frac{1}{16} by multiplying 2y^{\frac{3}{2}}x^{\frac{9}{4}} by the reciprocal of \frac{1}{16}.
32y^{\frac{3}{2}}x^{\frac{9}{4}}
Multiply 2 and 16 to get 32.