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\left(16^{\frac{2}{3}}\right)^{-\frac{3}{4}}
Use the rules of exponents to simplify the expression.
16^{\frac{2}{3}\left(-\frac{3}{4}\right)}
To raise a power to another power, multiply the exponents.
16^{-\frac{1}{2}}
Multiply \frac{2}{3} times -\frac{3}{4} by multiplying numerator times numerator and denominator times denominator. Then reduce the fraction to lowest terms if possible.
\frac{1}{4}
Raise 16 to the power -\frac{1}{2}.