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\left(-x^{5}\right)^{2}+8\left(-x^{5}\right)x+16x^{2}
Use binomial theorem \left(a+b\right)^{2}=a^{2}+2ab+b^{2} to expand \left(-x^{5}+4x\right)^{2}.
\left(x^{5}\right)^{2}+8\left(-x^{5}\right)x+16x^{2}
Calculate -x^{5} to the power of 2 and get \left(x^{5}\right)^{2}.
x^{10}+8\left(-x^{5}\right)x+16x^{2}
To raise a power to another power, multiply the exponents. Multiply 5 and 2 to get 10.
x^{10}+8\left(-1\right)x^{6}+16x^{2}
To multiply powers of the same base, add their exponents. Add 5 and 1 to get 6.
x^{10}-8x^{6}+16x^{2}
Multiply 8 and -1 to get -8.
\left(-x^{5}\right)^{2}+8\left(-x^{5}\right)x+16x^{2}
Use binomial theorem \left(a+b\right)^{2}=a^{2}+2ab+b^{2} to expand \left(-x^{5}+4x\right)^{2}.
\left(x^{5}\right)^{2}+8\left(-x^{5}\right)x+16x^{2}
Calculate -x^{5} to the power of 2 and get \left(x^{5}\right)^{2}.
x^{10}+8\left(-x^{5}\right)x+16x^{2}
To raise a power to another power, multiply the exponents. Multiply 5 and 2 to get 10.
x^{10}+8\left(-1\right)x^{6}+16x^{2}
To multiply powers of the same base, add their exponents. Add 5 and 1 to get 6.
x^{10}-8x^{6}+16x^{2}
Multiply 8 and -1 to get -8.