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Differentiate w.r.t. x
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\frac{-3zy^{2}x^{12}}{-x^{0}}\left(-\frac{3}{4}xy^{2}z^{3}\right)^{2}
Cancel out 2z^{3}y^{5} in both numerator and denominator.
\frac{-3zy^{2}x^{12}}{-1}\left(-\frac{3}{4}xy^{2}z^{3}\right)^{2}
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
3zy^{2}x^{12}\left(-\frac{3}{4}xy^{2}z^{3}\right)^{2}
Anything divided by -1 gives its opposite.
3zy^{2}x^{12}\left(-\frac{3}{4}\right)^{2}x^{2}\left(y^{2}\right)^{2}\left(z^{3}\right)^{2}
Expand \left(-\frac{3}{4}xy^{2}z^{3}\right)^{2}.
3zy^{2}x^{12}\left(-\frac{3}{4}\right)^{2}x^{2}y^{4}\left(z^{3}\right)^{2}
To raise a power to another power, multiply the exponents. Multiply 2 and 2 to get 4.
3zy^{2}x^{12}\left(-\frac{3}{4}\right)^{2}x^{2}y^{4}z^{6}
To raise a power to another power, multiply the exponents. Multiply 3 and 2 to get 6.
3zy^{2}x^{12}\times \frac{9}{16}x^{2}y^{4}z^{6}
Calculate -\frac{3}{4} to the power of 2 and get \frac{9}{16}.
\frac{27}{16}zy^{2}x^{12}x^{2}y^{4}z^{6}
Multiply 3 and \frac{9}{16} to get \frac{27}{16}.
\frac{27}{16}zy^{2}x^{14}y^{4}z^{6}
To multiply powers of the same base, add their exponents. Add 12 and 2 to get 14.
\frac{27}{16}zy^{6}x^{14}z^{6}
To multiply powers of the same base, add their exponents. Add 2 and 4 to get 6.
\frac{27}{16}z^{7}y^{6}x^{14}
To multiply powers of the same base, add their exponents. Add 1 and 6 to get 7.