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Differentiate w.r.t. x
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-5x^{-\frac{5}{12}}\times 4
To multiply powers of the same base, add their exponents. Add \frac{1}{3} and -\frac{3}{4} to get -\frac{5}{12}.
-20x^{-\frac{5}{12}}
Multiply -5 and 4 to get -20.
\frac{\mathrm{d}}{\mathrm{d}x}(-5x^{-\frac{5}{12}}\times 4)
To multiply powers of the same base, add their exponents. Add \frac{1}{3} and -\frac{3}{4} to get -\frac{5}{12}.
\frac{\mathrm{d}}{\mathrm{d}x}(-20x^{-\frac{5}{12}})
Multiply -5 and 4 to get -20.
-\frac{5}{12}\left(-20\right)x^{-\frac{5}{12}-1}
The derivative of ax^{n} is nax^{n-1}.
\frac{25}{3}x^{-\frac{5}{12}-1}
Multiply -\frac{5}{12} times -20.
\frac{25}{3}x^{-\frac{17}{12}}
Subtract 1 from -\frac{5}{12}.