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Differentiate w.r.t. a
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-5a^{2}a^{-10}
To raise a power to another power, multiply the exponents. Multiply -5 and 2 to get -10.
-5a^{-8}
To multiply powers of the same base, add their exponents. Add 2 and -10 to get -8.
\frac{\mathrm{d}}{\mathrm{d}a}(-5a^{2}a^{-10})
To raise a power to another power, multiply the exponents. Multiply -5 and 2 to get -10.
\frac{\mathrm{d}}{\mathrm{d}a}(-5a^{-8})
To multiply powers of the same base, add their exponents. Add 2 and -10 to get -8.
-8\left(-5\right)a^{-8-1}
The derivative of ax^{n} is nax^{n-1}.
40a^{-8-1}
Multiply -8 times -5.
40a^{-9}
Subtract 1 from -8.