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16\times 8\left(-2\right)^{500}
Calculate -4 to the power of 2 and get 16.
128\left(-2\right)^{500}
Multiply 16 and 8 to get 128.
128\times 3273390607896141870013189696827599152216642046043064789483291368096133796404674554883270092325904157150886684127560071009217256545885393053328527589376
Calculate -2 to the power of 500 and get 3273390607896141870013189696827599152216642046043064789483291368096133796404674554883270092325904157150886684127560071009217256545885393053328527589376.
418993997810706159361688281193932691483730181893512293053861295116305125939798343025058571817715732115313495568327689089179808837873330310826051531440128
Multiply 128 and 3273390607896141870013189696827599152216642046043064789483291368096133796404674554883270092325904157150886684127560071009217256545885393053328527589376 to get 418993997810706159361688281193932691483730181893512293053861295116305125939798343025058571817715732115313495568327689089179808837873330310826051531440128.