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-\frac{24+1}{8}-\frac{2\times 12+1}{12}
Multiply 3 and 8 to get 24.
-\frac{25}{8}-\frac{2\times 12+1}{12}
Add 24 and 1 to get 25.
-\frac{25}{8}-\frac{24+1}{12}
Multiply 2 and 12 to get 24.
-\frac{25}{8}-\frac{25}{12}
Add 24 and 1 to get 25.
-\frac{75}{24}-\frac{50}{24}
Least common multiple of 8 and 12 is 24. Convert -\frac{25}{8} and \frac{25}{12} to fractions with denominator 24.
\frac{-75-50}{24}
Since -\frac{75}{24} and \frac{50}{24} have the same denominator, subtract them by subtracting their numerators.
-\frac{125}{24}
Subtract 50 from -75 to get -125.