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\left(-2x^{2}y^{-2}\right)^{4}
Use the rules of exponents to simplify the expression.
\left(-2\right)^{4}\left(x^{2}\right)^{4}\left(y^{-2}\right)^{4}
To raise the product of two or more numbers to a power, raise each number to the power and take their product.
16\left(x^{2}\right)^{4}\left(y^{-2}\right)^{4}
Raise -2 to the power 4.
16x^{2\times 4}y^{-2\times 4}
To raise a power to another power, multiply the exponents.
16x^{8}y^{-2\times 4}
Multiply 2 times 4.
16x^{8}\times \frac{1}{y^{8}}
Multiply -2 times 4.
\left(-2x^{2}y^{-2}\right)^{4}
Use the rules of exponents to simplify the expression.
\left(-2\right)^{4}\left(x^{2}\right)^{4}\left(y^{-2}\right)^{4}
To raise the product of two or more numbers to a power, raise each number to the power and take their product.
16\left(x^{2}\right)^{4}\left(y^{-2}\right)^{4}
Raise -2 to the power 4.
16x^{2\times 4}y^{-2\times 4}
To raise a power to another power, multiply the exponents.
16x^{8}y^{-2\times 4}
Multiply 2 times 4.
16x^{8}\times \frac{1}{y^{8}}
Multiply -2 times 4.