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Evaluate
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Differentiate w.r.t. x
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-\frac{3}{8}x^{4}y^{2}z\left(-16\right)z^{2}
Multiply y and y to get y^{2}.
-\frac{3}{8}x^{4}y^{2}z^{3}\left(-16\right)
To multiply powers of the same base, add their exponents. Add 1 and 2 to get 3.
6x^{4}y^{2}z^{3}
Multiply -\frac{3}{8} and -16 to get 6.