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Differentiate w.r.t. a
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\frac{-\frac{2}{3}b^{2}c^{3}a^{5}}{-\frac{3}{4}}
Cancel out bc in both numerator and denominator.
\frac{-\frac{2}{3}b^{2}c^{3}a^{5}\times 4}{-3}
Divide -\frac{2}{3}b^{2}c^{3}a^{5} by -\frac{3}{4} by multiplying -\frac{2}{3}b^{2}c^{3}a^{5} by the reciprocal of -\frac{3}{4}.
\frac{-\frac{8}{3}b^{2}c^{3}a^{5}}{-3}
Multiply -\frac{2}{3} and 4 to get -\frac{8}{3}.
\frac{8}{9}b^{2}c^{3}a^{5}
Divide -\frac{8}{3}b^{2}c^{3}a^{5} by -3 to get \frac{8}{9}b^{2}c^{3}a^{5}.