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\left(-\frac{3}{6}+\frac{1}{6}-\frac{3}{8}+\frac{5}{12}\right)\left(-24\right)+0.25^{10}\times 4^{3}
Least common multiple of 2 and 6 is 6. Convert -\frac{1}{2} and \frac{1}{6} to fractions with denominator 6.
\left(\frac{-3+1}{6}-\frac{3}{8}+\frac{5}{12}\right)\left(-24\right)+0.25^{10}\times 4^{3}
Since -\frac{3}{6} and \frac{1}{6} have the same denominator, add them by adding their numerators.
\left(\frac{-2}{6}-\frac{3}{8}+\frac{5}{12}\right)\left(-24\right)+0.25^{10}\times 4^{3}
Add -3 and 1 to get -2.
\left(-\frac{1}{3}-\frac{3}{8}+\frac{5}{12}\right)\left(-24\right)+0.25^{10}\times 4^{3}
Reduce the fraction \frac{-2}{6} to lowest terms by extracting and canceling out 2.
\left(-\frac{8}{24}-\frac{9}{24}+\frac{5}{12}\right)\left(-24\right)+0.25^{10}\times 4^{3}
Least common multiple of 3 and 8 is 24. Convert -\frac{1}{3} and \frac{3}{8} to fractions with denominator 24.
\left(\frac{-8-9}{24}+\frac{5}{12}\right)\left(-24\right)+0.25^{10}\times 4^{3}
Since -\frac{8}{24} and \frac{9}{24} have the same denominator, subtract them by subtracting their numerators.
\left(-\frac{17}{24}+\frac{5}{12}\right)\left(-24\right)+0.25^{10}\times 4^{3}
Subtract 9 from -8 to get -17.
\left(-\frac{17}{24}+\frac{10}{24}\right)\left(-24\right)+0.25^{10}\times 4^{3}
Least common multiple of 24 and 12 is 24. Convert -\frac{17}{24} and \frac{5}{12} to fractions with denominator 24.
\frac{-17+10}{24}\left(-24\right)+0.25^{10}\times 4^{3}
Since -\frac{17}{24} and \frac{10}{24} have the same denominator, add them by adding their numerators.
-\frac{7}{24}\left(-24\right)+0.25^{10}\times 4^{3}
Add -17 and 10 to get -7.
\frac{-7\left(-24\right)}{24}+0.25^{10}\times 4^{3}
Express -\frac{7}{24}\left(-24\right) as a single fraction.
\frac{168}{24}+0.25^{10}\times 4^{3}
Multiply -7 and -24 to get 168.
7+0.25^{10}\times 4^{3}
Divide 168 by 24 to get 7.
7+0.00000095367431640625\times 4^{3}
Calculate 0.25 to the power of 10 and get 0.00000095367431640625.
7+0.00000095367431640625\times 64
Calculate 4 to the power of 3 and get 64.
7+0.00006103515625
Multiply 0.00000095367431640625 and 64 to get 0.00006103515625.
7.00006103515625
Add 7 and 0.00006103515625 to get 7.00006103515625.