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Differentiate w.r.t. x
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\left(\frac{x^{8}}{16y^{\frac{16}{3}}}\right)^{-\frac{1}{4}}
To divide powers of the same base, subtract the numerator's exponent from the denominator's exponent.
\frac{\left(x^{8}\right)^{-\frac{1}{4}}}{\left(16y^{\frac{16}{3}}\right)^{-\frac{1}{4}}}
To raise \frac{x^{8}}{16y^{\frac{16}{3}}} to a power, raise both numerator and denominator to the power and then divide.
\frac{x^{-2}}{\left(16y^{\frac{16}{3}}\right)^{-\frac{1}{4}}}
To raise a power to another power, multiply the exponents. Multiply 8 and -\frac{1}{4} to get -2.
\frac{x^{-2}}{16^{-\frac{1}{4}}\left(y^{\frac{16}{3}}\right)^{-\frac{1}{4}}}
Expand \left(16y^{\frac{16}{3}}\right)^{-\frac{1}{4}}.
\frac{x^{-2}}{16^{-\frac{1}{4}}y^{-\frac{4}{3}}}
To raise a power to another power, multiply the exponents. Multiply \frac{16}{3} and -\frac{1}{4} to get -\frac{4}{3}.
\frac{x^{-2}}{\frac{1}{2}y^{-\frac{4}{3}}}
Calculate 16 to the power of -\frac{1}{4} and get \frac{1}{2}.