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Differentiate w.r.t. x
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\frac{\mathrm{d}}{\mathrm{d}x}(\left(x^{5}\right)^{-\frac{3}{2}})
Cancel out xy in both numerator and denominator.
\frac{\mathrm{d}}{\mathrm{d}x}(x^{-\frac{15}{2}})
To raise a power to another power, multiply the exponents. Multiply 5 and -\frac{3}{2} to get -\frac{15}{2}.
-\frac{15}{2}x^{-\frac{15}{2}-1}
The derivative of ax^{n} is nax^{n-1}.
-\frac{15}{2}x^{-\frac{17}{2}}
Subtract 1 from -\frac{15}{2}.