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\frac{\left(x^{2}-1\right)\left(x^{2}-25\right)}{\left(x^{2}+3x-10\right)\left(x^{2}-3x-4\right)}
Divide \frac{x^{2}-1}{x^{2}+3x-10} by \frac{x^{2}-3x-4}{x^{2}-25} by multiplying \frac{x^{2}-1}{x^{2}+3x-10} by the reciprocal of \frac{x^{2}-3x-4}{x^{2}-25}.
\frac{\left(x-5\right)\left(x-1\right)\left(x+1\right)\left(x+5\right)}{\left(x-4\right)\left(x-2\right)\left(x+1\right)\left(x+5\right)}
Factor the expressions that are not already factored.
\frac{\left(x-5\right)\left(x-1\right)}{\left(x-4\right)\left(x-2\right)}
Cancel out \left(x+1\right)\left(x+5\right) in both numerator and denominator.
\frac{x^{2}-6x+5}{x^{2}-6x+8}
Expand the expression.
\frac{\left(x^{2}-1\right)\left(x^{2}-25\right)}{\left(x^{2}+3x-10\right)\left(x^{2}-3x-4\right)}
Divide \frac{x^{2}-1}{x^{2}+3x-10} by \frac{x^{2}-3x-4}{x^{2}-25} by multiplying \frac{x^{2}-1}{x^{2}+3x-10} by the reciprocal of \frac{x^{2}-3x-4}{x^{2}-25}.
\frac{\left(x-5\right)\left(x-1\right)\left(x+1\right)\left(x+5\right)}{\left(x-4\right)\left(x-2\right)\left(x+1\right)\left(x+5\right)}
Factor the expressions that are not already factored.
\frac{\left(x-5\right)\left(x-1\right)}{\left(x-4\right)\left(x-2\right)}
Cancel out \left(x+1\right)\left(x+5\right) in both numerator and denominator.
\frac{x^{2}-6x+5}{x^{2}-6x+8}
Expand the expression.