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\left(\frac{81}{16}\right)^{0\times 25}\left(-8\right)^{-\frac{4}{3}}a^{22}\times 2^{-2}
To multiply powers of the same base, add their exponents. Add -8 and 30 to get 22.
\left(\frac{81}{16}\right)^{0}\left(-8\right)^{-\frac{4}{3}}a^{22}\times 2^{-2}
Multiply 0 and 25 to get 0.
1\left(-8\right)^{-\frac{4}{3}}a^{22}\times 2^{-2}
Calculate \frac{81}{16} to the power of 0 and get 1.
1\times \frac{1}{16}a^{22}\times 2^{-2}
Calculate -8 to the power of -\frac{4}{3} and get \frac{1}{16}.
\frac{1}{16}a^{22}\times 2^{-2}
Multiply 1 and \frac{1}{16} to get \frac{1}{16}.
\frac{1}{16}a^{22}\times \frac{1}{4}
Calculate 2 to the power of -2 and get \frac{1}{4}.
\frac{1}{64}a^{22}
Multiply \frac{1}{16} and \frac{1}{4} to get \frac{1}{64}.
\frac{\mathrm{d}}{\mathrm{d}a}(\left(\frac{81}{16}\right)^{0\times 25}\left(-8\right)^{-\frac{4}{3}}a^{22}\times 2^{-2})
To multiply powers of the same base, add their exponents. Add -8 and 30 to get 22.
\frac{\mathrm{d}}{\mathrm{d}a}(\left(\frac{81}{16}\right)^{0}\left(-8\right)^{-\frac{4}{3}}a^{22}\times 2^{-2})
Multiply 0 and 25 to get 0.
\frac{\mathrm{d}}{\mathrm{d}a}(1\left(-8\right)^{-\frac{4}{3}}a^{22}\times 2^{-2})
Calculate \frac{81}{16} to the power of 0 and get 1.
\frac{\mathrm{d}}{\mathrm{d}a}(1\times \frac{1}{16}a^{22}\times 2^{-2})
Calculate -8 to the power of -\frac{4}{3} and get \frac{1}{16}.
\frac{\mathrm{d}}{\mathrm{d}a}(\frac{1}{16}a^{22}\times 2^{-2})
Multiply 1 and \frac{1}{16} to get \frac{1}{16}.
\frac{\mathrm{d}}{\mathrm{d}a}(\frac{1}{16}a^{22}\times \frac{1}{4})
Calculate 2 to the power of -2 and get \frac{1}{4}.
\frac{\mathrm{d}}{\mathrm{d}a}(\frac{1}{64}a^{22})
Multiply \frac{1}{16} and \frac{1}{4} to get \frac{1}{64}.
22\times \frac{1}{64}a^{22-1}
The derivative of ax^{n} is nax^{n-1}.
\frac{11}{32}a^{22-1}
Multiply 22 times \frac{1}{64}.
\frac{11}{32}a^{21}
Subtract 1 from 22.