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Differentiate w.r.t. a
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\frac{8b^{-4}a^{2}}{a^{-8}b^{-2}}\times \frac{-8a^{-2}}{-3b^{-3}}
Cancel out 4 in both numerator and denominator.
\frac{8b^{-4}a^{10}}{b^{-2}}\times \frac{-8a^{-2}}{-3b^{-3}}
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{8a^{10}}{b^{2}}\times \frac{-8a^{-2}}{-3b^{-3}}
To divide powers of the same base, subtract the numerator's exponent from the denominator's exponent.
\frac{8a^{10}\left(-8\right)a^{-2}}{b^{2}\left(-3\right)b^{-3}}
Multiply \frac{8a^{10}}{b^{2}} times \frac{-8a^{-2}}{-3b^{-3}} by multiplying numerator times numerator and denominator times denominator.
\frac{8a^{8}\left(-8\right)}{b^{2}\left(-3\right)b^{-3}}
To multiply powers of the same base, add their exponents. Add 10 and -2 to get 8.
\frac{8a^{8}\left(-8\right)}{b^{-1}\left(-3\right)}
To multiply powers of the same base, add their exponents. Add 2 and -3 to get -1.
\frac{-64a^{8}}{b^{-1}\left(-3\right)}
Multiply 8 and -8 to get -64.