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Differentiate w.r.t. x
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\frac{\frac{2}{3}x^{6}y^{5}}{-\frac{4}{15}x^{4}y^{4}}-2\left(-x\right)^{2}y+2xy\left(-3\right)x-\frac{3}{2}x^{2}y
Multiply -x and -x to get \left(-x\right)^{2}.
\frac{\frac{2}{3}x^{6}y^{5}}{-\frac{4}{15}x^{4}y^{4}}-2\left(-x\right)^{2}y+2x^{2}y\left(-3\right)-\frac{3}{2}x^{2}y
Multiply x and x to get x^{2}.
\frac{\frac{2}{3}yx^{2}}{-\frac{4}{15}}-2\left(-x\right)^{2}y+2x^{2}y\left(-3\right)-\frac{3}{2}x^{2}y
Cancel out x^{4}y^{4} in both numerator and denominator.
\frac{\frac{2}{3}yx^{2}\times 15}{-4}-2\left(-x\right)^{2}y+2x^{2}y\left(-3\right)-\frac{3}{2}x^{2}y
Divide \frac{2}{3}yx^{2} by -\frac{4}{15} by multiplying \frac{2}{3}yx^{2} by the reciprocal of -\frac{4}{15}.
\frac{10yx^{2}}{-4}-2\left(-x\right)^{2}y+2x^{2}y\left(-3\right)-\frac{3}{2}x^{2}y
Multiply \frac{2}{3} and 15 to get 10.
-\frac{5}{2}yx^{2}-2\left(-x\right)^{2}y+2x^{2}y\left(-3\right)-\frac{3}{2}x^{2}y
Divide 10yx^{2} by -4 to get -\frac{5}{2}yx^{2}.
-\frac{5}{2}yx^{2}-2x^{2}y+2x^{2}y\left(-3\right)-\frac{3}{2}x^{2}y
Calculate -x to the power of 2 and get x^{2}.
-\frac{9}{2}yx^{2}+2x^{2}y\left(-3\right)-\frac{3}{2}x^{2}y
Combine -\frac{5}{2}yx^{2} and -2x^{2}y to get -\frac{9}{2}yx^{2}.
-\frac{9}{2}yx^{2}-6x^{2}y-\frac{3}{2}x^{2}y
Multiply 2 and -3 to get -6.
-\frac{21}{2}yx^{2}-\frac{3}{2}x^{2}y
Combine -\frac{9}{2}yx^{2} and -6x^{2}y to get -\frac{21}{2}yx^{2}.
-12yx^{2}
Combine -\frac{21}{2}yx^{2} and -\frac{3}{2}x^{2}y to get -12yx^{2}.