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Differentiate w.r.t. a
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\frac{\mathrm{d}}{\mathrm{d}a}(\frac{1^{5}}{\left(a^{\frac{1}{2}}\right)^{5}})
To raise \frac{1}{a^{\frac{1}{2}}} to a power, raise both numerator and denominator to the power and then divide.
\frac{\mathrm{d}}{\mathrm{d}a}(\frac{1^{5}}{a^{\frac{5}{2}}})
To raise a power to another power, multiply the exponents. Multiply \frac{1}{2} and 5 to get \frac{5}{2}.
\frac{\mathrm{d}}{\mathrm{d}a}(\frac{1}{a^{\frac{5}{2}}})
Calculate 1 to the power of 5 and get 1.
-\left(a^{\frac{5}{2}}\right)^{-1-1}\frac{\mathrm{d}}{\mathrm{d}a}(a^{\frac{5}{2}})
If F is the composition of two differentiable functions f\left(u\right) and u=g\left(x\right), that is, if F\left(x\right)=f\left(g\left(x\right)\right), then the derivative of F is the derivative of f with respect to u times the derivative of g with respect to x, that is, \frac{\mathrm{d}}{\mathrm{d}x}(F)\left(x\right)=\frac{\mathrm{d}}{\mathrm{d}x}(f)\left(g\left(x\right)\right)\frac{\mathrm{d}}{\mathrm{d}x}(g)\left(x\right).
-\left(a^{\frac{5}{2}}\right)^{-2}\times \frac{5}{2}a^{\frac{5}{2}-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
-\frac{5}{2}a^{\frac{3}{2}}\left(a^{\frac{5}{2}}\right)^{-2}
Simplify.