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Differentiate w.r.t. x
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\frac{\left(-8x^{3}\right)^{\frac{2}{3}}}{\left(y^{-6}\right)^{\frac{2}{3}}}
To raise \frac{-8x^{3}}{y^{-6}} to a power, raise both numerator and denominator to the power and then divide.
\frac{\left(-8x^{3}\right)^{\frac{2}{3}}}{y^{-4}}
To raise a power to another power, multiply the exponents. Multiply -6 and \frac{2}{3} to get -4.
\frac{\left(-8\right)^{\frac{2}{3}}\left(x^{3}\right)^{\frac{2}{3}}}{y^{-4}}
Expand \left(-8x^{3}\right)^{\frac{2}{3}}.
\frac{\left(-8\right)^{\frac{2}{3}}x^{2}}{y^{-4}}
To raise a power to another power, multiply the exponents. Multiply 3 and \frac{2}{3} to get 2.
\frac{4x^{2}}{y^{-4}}
Calculate -8 to the power of \frac{2}{3} and get 4.