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Differentiate w.r.t. x
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\frac{\left(-64x^{3}\right)^{\frac{2}{3}}}{\left(z^{6}y^{9}\right)^{\frac{2}{3}}}
To raise \frac{-64x^{3}}{z^{6}y^{9}} to a power, raise both numerator and denominator to the power and then divide.
\frac{\left(-64\right)^{\frac{2}{3}}\left(x^{3}\right)^{\frac{2}{3}}}{\left(z^{6}y^{9}\right)^{\frac{2}{3}}}
Expand \left(-64x^{3}\right)^{\frac{2}{3}}.
\frac{\left(-64\right)^{\frac{2}{3}}x^{2}}{\left(z^{6}y^{9}\right)^{\frac{2}{3}}}
To raise a power to another power, multiply the exponents. Multiply 3 and \frac{2}{3} to get 2.
\frac{16x^{2}}{\left(z^{6}y^{9}\right)^{\frac{2}{3}}}
Calculate -64 to the power of \frac{2}{3} and get 16.
\frac{16x^{2}}{\left(z^{6}\right)^{\frac{2}{3}}\left(y^{9}\right)^{\frac{2}{3}}}
Expand \left(z^{6}y^{9}\right)^{\frac{2}{3}}.
\frac{16x^{2}}{z^{4}\left(y^{9}\right)^{\frac{2}{3}}}
To raise a power to another power, multiply the exponents. Multiply 6 and \frac{2}{3} to get 4.
\frac{16x^{2}}{z^{4}y^{6}}
To raise a power to another power, multiply the exponents. Multiply 9 and \frac{2}{3} to get 6.