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Evaluate
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Differentiate w.r.t. x
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\frac{\frac{16}{3}yzx^{2}}{-\frac{4}{27}}
Cancel out z^{2}x^{3}y^{4} in both numerator and denominator.
\frac{\frac{16}{3}yzx^{2}\times 27}{-4}
Divide \frac{16}{3}yzx^{2} by -\frac{4}{27} by multiplying \frac{16}{3}yzx^{2} by the reciprocal of -\frac{4}{27}.
\frac{144yzx^{2}}{-4}
Multiply \frac{16}{3} and 27 to get 144.
-36yzx^{2}
Divide 144yzx^{2} by -4 to get -36yzx^{2}.
\frac{\mathrm{d}}{\mathrm{d}x}(\frac{16z^{3}y^{5}}{3\left(-\frac{4z^{2}y^{4}}{27}\right)}x^{5-3})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}x}(\left(-36yz\right)x^{2})
Do the arithmetic.
2\left(-36yz\right)x^{2-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
\left(-72yz\right)x^{1}
Do the arithmetic.
\left(-72yz\right)x
For any term t, t^{1}=t.