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Differentiate w.r.t. y
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\frac{\mathrm{d}}{\mathrm{d}y}(\frac{1}{1}y^{-12-21})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}y}(y^{-33})
Do the arithmetic.
-33y^{-33-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
-33y^{-34}
Do the arithmetic.
\frac{1}{y^{33}}
Rewrite y^{21} as y^{-12}y^{33}. Cancel out y^{-12} in both numerator and denominator.