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Differentiate w.r.t. x
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x^{4}+2x^{3}-5x^{2}-18x-\frac{36}{\left(x-3\right)\left(x+3\right)}
Factor x^{2}-9.
\frac{\left(x^{4}+2x^{3}-5x^{2}-18x\right)\left(x-3\right)\left(x+3\right)}{\left(x-3\right)\left(x+3\right)}-\frac{36}{\left(x-3\right)\left(x+3\right)}
To add or subtract expressions, expand them to make their denominators the same. Multiply x^{4}+2x^{3}-5x^{2}-18x times \frac{\left(x-3\right)\left(x+3\right)}{\left(x-3\right)\left(x+3\right)}.
\frac{\left(x^{4}+2x^{3}-5x^{2}-18x\right)\left(x-3\right)\left(x+3\right)-36}{\left(x-3\right)\left(x+3\right)}
Since \frac{\left(x^{4}+2x^{3}-5x^{2}-18x\right)\left(x-3\right)\left(x+3\right)}{\left(x-3\right)\left(x+3\right)} and \frac{36}{\left(x-3\right)\left(x+3\right)} have the same denominator, subtract them by subtracting their numerators.
\frac{x^{6}-9x^{4}+2x^{5}-18x^{3}-5x^{4}+45x^{2}-18x^{3}+162x-36}{\left(x-3\right)\left(x+3\right)}
Do the multiplications in \left(x^{4}+2x^{3}-5x^{2}-18x\right)\left(x-3\right)\left(x+3\right)-36.
\frac{162x+x^{6}-14x^{4}+2x^{5}-36x^{3}+45x^{2}-36}{\left(x-3\right)\left(x+3\right)}
Combine like terms in x^{6}-9x^{4}+2x^{5}-18x^{3}-5x^{4}+45x^{2}-18x^{3}+162x-36.
\frac{162x+x^{6}-14x^{4}+2x^{5}-36x^{3}+45x^{2}-36}{x^{2}-9}
Expand \left(x-3\right)\left(x+3\right).