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Differentiate w.r.t. x
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\frac{\mathrm{d}}{\mathrm{d}x}(-4x^{2}-4x^{8}+x+8)
Combine x^{2} and -5x^{2} to get -4x^{2}.
2\left(-4\right)x^{2-1}+8\left(-4\right)x^{8-1}+x^{1-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
-8x^{2-1}+8\left(-4\right)x^{8-1}+x^{1-1}
Multiply 2 times -4.
-8x^{1}+8\left(-4\right)x^{8-1}+x^{1-1}
Subtract 1 from 2.
-8x^{1}-32x^{8-1}+x^{1-1}
Multiply 8 times -4.
-8x^{1}-32x^{7}+x^{1-1}
Subtract 1 from 8.
-8x^{1}-32x^{7}+x^{0}
Subtract 1 from 1.
-8x-32x^{7}+x^{0}
For any term t, t^{1}=t.
-8x-32x^{7}+1
For any term t except 0, t^{0}=1.
-4x^{2}-4x^{8}+x+8
Combine x^{2} and -5x^{2} to get -4x^{2}.