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Differentiate w.r.t. x
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\frac{1}{4}x^{\frac{1}{4}-1}+\frac{1}{2}\left(-2\right)x^{\frac{1}{2}-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
\frac{1}{4}x^{-\frac{3}{4}}+\frac{1}{2}\left(-2\right)x^{\frac{1}{2}-1}
Subtract 1 from \frac{1}{4}.
\frac{1}{4}x^{-\frac{3}{4}}-x^{\frac{1}{2}-1}
Multiply \frac{1}{2} times -2.
\frac{1}{4}x^{-\frac{3}{4}}-x^{-\frac{1}{2}}
Subtract 1 from \frac{1}{2}.