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Evaluate
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Differentiate w.r.t. x
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16x^{2}y^{2}z^{2}\times \frac{4^{2}x^{2}y^{2}z^{2}}{2^{2}x^{2}y^{2}z^{2}}
Calculate 4 to the power of 2 and get 16.
16x^{2}y^{2}z^{2}\times \frac{4^{2}}{2^{2}}
Cancel out x^{2}y^{2}z^{2} in both numerator and denominator.
16x^{2}y^{2}z^{2}\times \frac{16}{2^{2}}
Calculate 4 to the power of 2 and get 16.
16x^{2}y^{2}z^{2}\times \frac{16}{4}
Calculate 2 to the power of 2 and get 4.
16x^{2}y^{2}z^{2}\times 4
Divide 16 by 4 to get 4.
64x^{2}y^{2}z^{2}
Multiply 16 and 4 to get 64.