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2^{5-\left(-16\right)-\left(-2^{3}\right)-2^{2}}
Calculate 2 to the power of 4 and get 16.
2^{5+16-\left(-2^{3}\right)-2^{2}}
The opposite of -16 is 16.
2^{21-\left(-2^{3}\right)-2^{2}}
Add 5 and 16 to get 21.
2^{21-\left(-8\right)-2^{2}}
Calculate 2 to the power of 3 and get 8.
2^{21+8-2^{2}}
The opposite of -8 is 8.
2^{29-2^{2}}
Add 21 and 8 to get 29.
2^{29-4}
Calculate 2 to the power of 2 and get 4.
2^{25}
Subtract 4 from 29 to get 25.
33554432
Calculate 2 to the power of 25 and get 33554432.