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25x^{2}+20xy+4y^{2}-\left(2x+5y\right)^{2}
Use binomial theorem \left(a+b\right)^{2}=a^{2}+2ab+b^{2} to expand \left(5x+2y\right)^{2}.
25x^{2}+20xy+4y^{2}-\left(4x^{2}+20xy+25y^{2}\right)
Use binomial theorem \left(a+b\right)^{2}=a^{2}+2ab+b^{2} to expand \left(2x+5y\right)^{2}.
25x^{2}+20xy+4y^{2}-4x^{2}-20xy-25y^{2}
To find the opposite of 4x^{2}+20xy+25y^{2}, find the opposite of each term.
21x^{2}+20xy+4y^{2}-20xy-25y^{2}
Combine 25x^{2} and -4x^{2} to get 21x^{2}.
21x^{2}+4y^{2}-25y^{2}
Combine 20xy and -20xy to get 0.
21x^{2}-21y^{2}
Combine 4y^{2} and -25y^{2} to get -21y^{2}.
25x^{2}+20xy+4y^{2}-\left(2x+5y\right)^{2}
Use binomial theorem \left(a+b\right)^{2}=a^{2}+2ab+b^{2} to expand \left(5x+2y\right)^{2}.
25x^{2}+20xy+4y^{2}-\left(4x^{2}+20xy+25y^{2}\right)
Use binomial theorem \left(a+b\right)^{2}=a^{2}+2ab+b^{2} to expand \left(2x+5y\right)^{2}.
25x^{2}+20xy+4y^{2}-4x^{2}-20xy-25y^{2}
To find the opposite of 4x^{2}+20xy+25y^{2}, find the opposite of each term.
21x^{2}+20xy+4y^{2}-20xy-25y^{2}
Combine 25x^{2} and -4x^{2} to get 21x^{2}.
21x^{2}+4y^{2}-25y^{2}
Combine 20xy and -20xy to get 0.
21x^{2}-21y^{2}
Combine 4y^{2} and -25y^{2} to get -21y^{2}.