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16+16x+4x^{2}=\left(2\sqrt{x^{2}+1}\right)^{2}
Use binomial theorem \left(a+b\right)^{2}=a^{2}+2ab+b^{2} to expand \left(4+2x\right)^{2}.
16+16x+4x^{2}=2^{2}\left(\sqrt{x^{2}+1}\right)^{2}
Expand \left(2\sqrt{x^{2}+1}\right)^{2}.
16+16x+4x^{2}=4\left(\sqrt{x^{2}+1}\right)^{2}
Calculate 2 to the power of 2 and get 4.
16+16x+4x^{2}=4\left(x^{2}+1\right)
Calculate \sqrt{x^{2}+1} to the power of 2 and get x^{2}+1.
16+16x+4x^{2}=4x^{2}+4
Use the distributive property to multiply 4 by x^{2}+1.
16+16x+4x^{2}-4x^{2}=4
Subtract 4x^{2} from both sides.
16+16x=4
Combine 4x^{2} and -4x^{2} to get 0.
16x=4-16
Subtract 16 from both sides.
16x=-12
Subtract 16 from 4 to get -12.
x=\frac{-12}{16}
Divide both sides by 16.
x=-\frac{3}{4}
Reduce the fraction \frac{-12}{16} to lowest terms by extracting and canceling out 4.