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\left(-2\right)^{2}x^{2}-\left(2x+5\right)\left(2x-5\right)
Expand \left(-2x\right)^{2}.
4x^{2}-\left(2x+5\right)\left(2x-5\right)
Calculate -2 to the power of 2 and get 4.
4x^{2}-\left(\left(2x\right)^{2}-25\right)
Consider \left(2x+5\right)\left(2x-5\right). Multiplication can be transformed into difference of squares using the rule: \left(a-b\right)\left(a+b\right)=a^{2}-b^{2}. Square 5.
4x^{2}-\left(2^{2}x^{2}-25\right)
Expand \left(2x\right)^{2}.
4x^{2}-\left(4x^{2}-25\right)
Calculate 2 to the power of 2 and get 4.
4x^{2}-4x^{2}+25
To find the opposite of 4x^{2}-25, find the opposite of each term.
25
Combine 4x^{2} and -4x^{2} to get 0.