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\left(-x^{2}\right)^{2}+8\left(-x^{2}\right)+16+2\left(-x^{2}+4\right)-3
Use binomial theorem \left(a+b\right)^{2}=a^{2}+2ab+b^{2} to expand \left(-x^{2}+4\right)^{2}.
\left(x^{2}\right)^{2}+8\left(-x^{2}\right)+16+2\left(-x^{2}+4\right)-3
Calculate -x^{2} to the power of 2 and get \left(x^{2}\right)^{2}.
\left(x^{2}\right)^{2}+8\left(-x^{2}\right)+16+2\left(-x^{2}\right)+8-3
Use the distributive property to multiply 2 by -x^{2}+4.
\left(x^{2}\right)^{2}+10\left(-x^{2}\right)+16+8-3
Combine 8\left(-x^{2}\right) and 2\left(-x^{2}\right) to get 10\left(-x^{2}\right).
\left(x^{2}\right)^{2}+10\left(-x^{2}\right)+24-3
Add 16 and 8 to get 24.
\left(x^{2}\right)^{2}+10\left(-x^{2}\right)+21
Subtract 3 from 24 to get 21.
x^{4}+10\left(-x^{2}\right)+21
To raise a power to another power, multiply the exponents. Multiply 2 and 2 to get 4.
x^{4}-10x^{2}+21
Multiply 10 and -1 to get -10.
\left(-x^{2}\right)^{2}+8\left(-x^{2}\right)+16+2\left(-x^{2}+4\right)-3
Use binomial theorem \left(a+b\right)^{2}=a^{2}+2ab+b^{2} to expand \left(-x^{2}+4\right)^{2}.
\left(x^{2}\right)^{2}+8\left(-x^{2}\right)+16+2\left(-x^{2}+4\right)-3
Calculate -x^{2} to the power of 2 and get \left(x^{2}\right)^{2}.
\left(x^{2}\right)^{2}+8\left(-x^{2}\right)+16+2\left(-x^{2}\right)+8-3
Use the distributive property to multiply 2 by -x^{2}+4.
\left(x^{2}\right)^{2}+10\left(-x^{2}\right)+16+8-3
Combine 8\left(-x^{2}\right) and 2\left(-x^{2}\right) to get 10\left(-x^{2}\right).
\left(x^{2}\right)^{2}+10\left(-x^{2}\right)+24-3
Add 16 and 8 to get 24.
\left(x^{2}\right)^{2}+10\left(-x^{2}\right)+21
Subtract 3 from 24 to get 21.
x^{4}+10\left(-x^{2}\right)+21
To raise a power to another power, multiply the exponents. Multiply 2 and 2 to get 4.
x^{4}-10x^{2}+21
Multiply 10 and -1 to get -10.