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Differentiate w.r.t. x
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\frac{\left(81y^{16}\right)^{\frac{1}{2}}}{\left(16x^{12}\right)^{\frac{1}{2}}}
To raise \frac{81y^{16}}{16x^{12}} to a power, raise both numerator and denominator to the power and then divide.
\frac{81^{\frac{1}{2}}\left(y^{16}\right)^{\frac{1}{2}}}{\left(16x^{12}\right)^{\frac{1}{2}}}
Expand \left(81y^{16}\right)^{\frac{1}{2}}.
\frac{81^{\frac{1}{2}}y^{8}}{\left(16x^{12}\right)^{\frac{1}{2}}}
To raise a power to another power, multiply the exponents. Multiply 16 and \frac{1}{2} to get 8.
\frac{9y^{8}}{\left(16x^{12}\right)^{\frac{1}{2}}}
Calculate 81 to the power of \frac{1}{2} and get 9.
\frac{9y^{8}}{16^{\frac{1}{2}}\left(x^{12}\right)^{\frac{1}{2}}}
Expand \left(16x^{12}\right)^{\frac{1}{2}}.
\frac{9y^{8}}{16^{\frac{1}{2}}x^{6}}
To raise a power to another power, multiply the exponents. Multiply 12 and \frac{1}{2} to get 6.
\frac{9y^{8}}{4x^{6}}
Calculate 16 to the power of \frac{1}{2} and get 4.