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Differentiate w.r.t. x
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\left(\frac{8a^{3}x^{-3}}{27}\right)^{1}\times \frac{2}{3}\times \left(\frac{64a^{3}}{27}x^{-3}\right)^{1}\times \frac{-2}{3}
Express \frac{8a^{3}}{27}x^{-3} as a single fraction.
\frac{8a^{3}x^{-3}}{27}\times \frac{2}{3}\times \left(\frac{64a^{3}}{27}x^{-3}\right)^{1}\times \frac{-2}{3}
Calculate \frac{8a^{3}x^{-3}}{27} to the power of 1 and get \frac{8a^{3}x^{-3}}{27}.
\frac{8a^{3}x^{-3}}{27}\times \frac{2}{3}\times \left(\frac{64a^{3}x^{-3}}{27}\right)^{1}\times \frac{-2}{3}
Express \frac{64a^{3}}{27}x^{-3} as a single fraction.
\frac{8a^{3}x^{-3}}{27}\times \frac{2}{3}\times \frac{64a^{3}x^{-3}}{27}\times \frac{-2}{3}
Calculate \frac{64a^{3}x^{-3}}{27} to the power of 1 and get \frac{64a^{3}x^{-3}}{27}.
\frac{8a^{3}x^{-3}}{27}\times \frac{2}{3}\times \frac{64a^{3}x^{-3}}{27}\left(-\frac{2}{3}\right)
Fraction \frac{-2}{3} can be rewritten as -\frac{2}{3} by extracting the negative sign.
\frac{8a^{3}x^{-3}}{27}\left(-\frac{4}{9}\right)\times \frac{64a^{3}x^{-3}}{27}
Multiply \frac{2}{3} and -\frac{2}{3} to get -\frac{4}{9}.
\frac{-8a^{3}x^{-3}\times 4}{27\times 9}\times \frac{64a^{3}x^{-3}}{27}
Multiply \frac{8a^{3}x^{-3}}{27} times -\frac{4}{9} by multiplying numerator times numerator and denominator times denominator.
\frac{-8a^{3}x^{-3}\times 4\times 64a^{3}x^{-3}}{27\times 9\times 27}
Multiply \frac{-8a^{3}x^{-3}\times 4}{27\times 9} times \frac{64a^{3}x^{-3}}{27} by multiplying numerator times numerator and denominator times denominator.
\frac{-8a^{6}x^{-3}\times 4\times 64x^{-3}}{27\times 9\times 27}
To multiply powers of the same base, add their exponents. Add 3 and 3 to get 6.
\frac{-8a^{6}x^{-6}\times 4\times 64}{27\times 9\times 27}
To multiply powers of the same base, add their exponents. Add -3 and -3 to get -6.
\frac{-32a^{6}x^{-6}\times 64}{27\times 9\times 27}
Multiply -8 and 4 to get -32.
\frac{-2048a^{6}x^{-6}}{27\times 9\times 27}
Multiply -32 and 64 to get -2048.
\frac{-2048a^{6}x^{-6}}{243\times 27}
Multiply 27 and 9 to get 243.
\frac{-2048a^{6}x^{-6}}{6561}
Multiply 243 and 27 to get 6561.