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Differentiate w.r.t. x
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hoe\left(-2\right)^{4}\times 4^{-2}x
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
hoe\left(-2\right)^{4}\times \frac{1}{16}x
Calculate 4 to the power of -2 and get \frac{1}{16}.
hoe\times 16\times \frac{1}{16}x
Calculate -2 to the power of 4 and get 16.
hoex
Multiply 16 and \frac{1}{16} to get 1.