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-3\left(1+6\right)-\left(-5\left(-2\right)+3\left(-2-4\right)\right)-2-2^{2}-2^{3}-2^{4}
Add -2 and 3 to get 1.
-3\times 7-\left(-5\left(-2\right)+3\left(-2-4\right)\right)-2-2^{2}-2^{3}-2^{4}
Add 1 and 6 to get 7.
-21-\left(-5\left(-2\right)+3\left(-2-4\right)\right)-2-2^{2}-2^{3}-2^{4}
Multiply -3 and 7 to get -21.
-21-\left(10+3\left(-2-4\right)\right)-2-2^{2}-2^{3}-2^{4}
Multiply -5 and -2 to get 10.
-21-\left(10+3\left(-6\right)\right)-2-2^{2}-2^{3}-2^{4}
Subtract 4 from -2 to get -6.
-21-\left(10-18\right)-2-2^{2}-2^{3}-2^{4}
Multiply 3 and -6 to get -18.
-21-\left(-8\right)-2-2^{2}-2^{3}-2^{4}
Subtract 18 from 10 to get -8.
-21+8-2-2^{2}-2^{3}-2^{4}
The opposite of -8 is 8.
-13-2-2^{2}-2^{3}-2^{4}
Add -21 and 8 to get -13.
-15-2^{2}-2^{3}-2^{4}
Subtract 2 from -13 to get -15.
-15-4-2^{3}-2^{4}
Calculate 2 to the power of 2 and get 4.
-19-2^{3}-2^{4}
Subtract 4 from -15 to get -19.
-19-8-2^{4}
Calculate 2 to the power of 3 and get 8.
-27-2^{4}
Subtract 8 from -19 to get -27.
-27-16
Calculate 2 to the power of 4 and get 16.
-43
Subtract 16 from -27 to get -43.