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-\frac{1}{4}-\frac{4}{5}\times \frac{12+1}{6}-\frac{5}{16}
Multiply 2 and 6 to get 12.
-\frac{1}{4}-\frac{4}{5}\times \frac{13}{6}-\frac{5}{16}
Add 12 and 1 to get 13.
-\frac{1}{4}+\frac{-4\times 13}{5\times 6}-\frac{5}{16}
Multiply -\frac{4}{5} times \frac{13}{6} by multiplying numerator times numerator and denominator times denominator.
-\frac{1}{4}+\frac{-52}{30}-\frac{5}{16}
Do the multiplications in the fraction \frac{-4\times 13}{5\times 6}.
-\frac{1}{4}-\frac{26}{15}-\frac{5}{16}
Reduce the fraction \frac{-52}{30} to lowest terms by extracting and canceling out 2.
-\frac{15}{60}-\frac{104}{60}-\frac{5}{16}
Least common multiple of 4 and 15 is 60. Convert -\frac{1}{4} and \frac{26}{15} to fractions with denominator 60.
\frac{-15-104}{60}-\frac{5}{16}
Since -\frac{15}{60} and \frac{104}{60} have the same denominator, subtract them by subtracting their numerators.
-\frac{119}{60}-\frac{5}{16}
Subtract 104 from -15 to get -119.
-\frac{476}{240}-\frac{75}{240}
Least common multiple of 60 and 16 is 240. Convert -\frac{119}{60} and \frac{5}{16} to fractions with denominator 240.
\frac{-476-75}{240}
Since -\frac{476}{240} and \frac{75}{240} have the same denominator, subtract them by subtracting their numerators.
-\frac{551}{240}
Subtract 75 from -476 to get -551.