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\left(2x\right)^{2}-\left(5y\right)^{2}+\left(2x+y\right)\left(-2x-y\right)
Consider \left(2x+5y\right)\left(2x-5y\right). Multiplication can be transformed into difference of squares using the rule: \left(a-b\right)\left(a+b\right)=a^{2}-b^{2}.
2^{2}x^{2}-\left(5y\right)^{2}+\left(2x+y\right)\left(-2x-y\right)
Expand \left(2x\right)^{2}.
4x^{2}-\left(5y\right)^{2}+\left(2x+y\right)\left(-2x-y\right)
Calculate 2 to the power of 2 and get 4.
4x^{2}-5^{2}y^{2}+\left(2x+y\right)\left(-2x-y\right)
Expand \left(5y\right)^{2}.
4x^{2}-25y^{2}+\left(2x+y\right)\left(-2x-y\right)
Calculate 5 to the power of 2 and get 25.
4x^{2}-25y^{2}-4x^{2}-2xy-2yx-y^{2}
Apply the distributive property by multiplying each term of 2x+y by each term of -2x-y.
4x^{2}-25y^{2}-4x^{2}-4xy-y^{2}
Combine -2xy and -2yx to get -4xy.
-25y^{2}-4xy-y^{2}
Combine 4x^{2} and -4x^{2} to get 0.
-26y^{2}-4xy
Combine -25y^{2} and -y^{2} to get -26y^{2}.
\left(2x\right)^{2}-\left(5y\right)^{2}+\left(2x+y\right)\left(-2x-y\right)
Consider \left(2x+5y\right)\left(2x-5y\right). Multiplication can be transformed into difference of squares using the rule: \left(a-b\right)\left(a+b\right)=a^{2}-b^{2}.
2^{2}x^{2}-\left(5y\right)^{2}+\left(2x+y\right)\left(-2x-y\right)
Expand \left(2x\right)^{2}.
4x^{2}-\left(5y\right)^{2}+\left(2x+y\right)\left(-2x-y\right)
Calculate 2 to the power of 2 and get 4.
4x^{2}-5^{2}y^{2}+\left(2x+y\right)\left(-2x-y\right)
Expand \left(5y\right)^{2}.
4x^{2}-25y^{2}+\left(2x+y\right)\left(-2x-y\right)
Calculate 5 to the power of 2 and get 25.
4x^{2}-25y^{2}-4x^{2}-2xy-2yx-y^{2}
Apply the distributive property by multiplying each term of 2x+y by each term of -2x-y.
4x^{2}-25y^{2}-4x^{2}-4xy-y^{2}
Combine -2xy and -2yx to get -4xy.
-25y^{2}-4xy-y^{2}
Combine 4x^{2} and -4x^{2} to get 0.
-26y^{2}-4xy
Combine -25y^{2} and -y^{2} to get -26y^{2}.