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\int _{2}^{4}x^{2}+16x+64\mathrm{d}x
Use binomial theorem \left(a+b\right)^{2}=a^{2}+2ab+b^{2} to expand \left(x+8\right)^{2}.
\int x^{2}+16x+64\mathrm{d}x
Evaluate the indefinite integral first.
\int x^{2}\mathrm{d}x+\int 16x\mathrm{d}x+\int 64\mathrm{d}x
Integrate the sum term by term.
\int x^{2}\mathrm{d}x+16\int x\mathrm{d}x+\int 64\mathrm{d}x
Factor out the constant in each of the terms.
\frac{x^{3}}{3}+16\int x\mathrm{d}x+\int 64\mathrm{d}x
Since \int x^{k}\mathrm{d}x=\frac{x^{k+1}}{k+1} for k\neq -1, replace \int x^{2}\mathrm{d}x with \frac{x^{3}}{3}.
\frac{x^{3}}{3}+8x^{2}+\int 64\mathrm{d}x
Since \int x^{k}\mathrm{d}x=\frac{x^{k+1}}{k+1} for k\neq -1, replace \int x\mathrm{d}x with \frac{x^{2}}{2}. Multiply 16 times \frac{x^{2}}{2}.
\frac{x^{3}}{3}+8x^{2}+64x
Find the integral of 64 using the table of common integrals rule \int a\mathrm{d}x=ax.
\frac{4^{3}}{3}+8\times 4^{2}+64\times 4-\left(\frac{2^{3}}{3}+8\times 2^{2}+64\times 2\right)
The definite integral is the antiderivative of the expression evaluated at the upper limit of integration minus the antiderivative evaluated at the lower limit of integration.
\frac{728}{3}
Simplify.