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\int \frac{4}{x^{3}}\mathrm{d}x
Evaluate the indefinite integral first.
4\int \frac{1}{x^{3}}\mathrm{d}x
Factor out the constant using \int af\left(x\right)\mathrm{d}x=a\int f\left(x\right)\mathrm{d}x.
-\frac{2}{x^{2}}
Since \int x^{k}\mathrm{d}x=\frac{x^{k+1}}{k+1} for k\neq -1, replace \int \frac{1}{x^{3}}\mathrm{d}x with -\frac{1}{2x^{2}}. Multiply 4 times -\frac{1}{2x^{2}}.
-2\times 100^{-2}+2\times 1^{-2}
The definite integral is the antiderivative of the expression evaluated at the upper limit of integration minus the antiderivative evaluated at the lower limit of integration.
\frac{9999}{5000}
Simplify.