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Differentiate w.r.t. x
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\frac{\mathrm{d}}{\mathrm{d}x}(\left(4\left(x^{4}\right)^{2}+8x^{4}x+4x^{2}\right)\times 4x^{2})
Use binomial theorem \left(a+b\right)^{2}=a^{2}+2ab+b^{2} to expand \left(2x^{4}+2x\right)^{2}.
\frac{\mathrm{d}}{\mathrm{d}x}(\left(4x^{8}+8x^{4}x+4x^{2}\right)\times 4x^{2})
To raise a power to another power, multiply the exponents. Multiply 4 and 2 to get 8.
\frac{\mathrm{d}}{\mathrm{d}x}(\left(4x^{8}+8x^{5}+4x^{2}\right)\times 4x^{2})
To multiply powers of the same base, add their exponents. Add 4 and 1 to get 5.
\frac{\mathrm{d}}{\mathrm{d}x}(\left(16x^{8}+32x^{5}+16x^{2}\right)x^{2})
Use the distributive property to multiply 4x^{8}+8x^{5}+4x^{2} by 4.
\frac{\mathrm{d}}{\mathrm{d}x}(16x^{10}+32x^{7}+16x^{4})
Use the distributive property to multiply 16x^{8}+32x^{5}+16x^{2} by x^{2}.
10\times 16x^{10-1}+7\times 32x^{7-1}+4\times 16x^{4-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
160x^{10-1}+7\times 32x^{7-1}+4\times 16x^{4-1}
Multiply 10 times 16.
160x^{9}+7\times 32x^{7-1}+4\times 16x^{4-1}
Subtract 1 from 10.
160x^{9}+224x^{7-1}+4\times 16x^{4-1}
Multiply 7 times 32.
160x^{9}+224x^{6}+4\times 16x^{4-1}
Subtract 1 from 7.
160x^{9}+224x^{6}+64x^{4-1}
Multiply 7 times 32.
160x^{9}+224x^{6}+64x^{3}
Subtract 1 from 4.