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Differentiate w.r.t. x
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\frac{x\left(x_{2}-4\right)}{\left(x-2\right)\left(x_{2}-4\right)}-\frac{8\left(x-2\right)}{\left(x-2\right)\left(x_{2}-4\right)}
To add or subtract expressions, expand them to make their denominators the same. Least common multiple of x-2 and x_{2}-4 is \left(x-2\right)\left(x_{2}-4\right). Multiply \frac{x}{x-2} times \frac{x_{2}-4}{x_{2}-4}. Multiply \frac{8}{x_{2}-4} times \frac{x-2}{x-2}.
\frac{x\left(x_{2}-4\right)-8\left(x-2\right)}{\left(x-2\right)\left(x_{2}-4\right)}
Since \frac{x\left(x_{2}-4\right)}{\left(x-2\right)\left(x_{2}-4\right)} and \frac{8\left(x-2\right)}{\left(x-2\right)\left(x_{2}-4\right)} have the same denominator, subtract them by subtracting their numerators.
\frac{xx_{2}-4x-8x+16}{\left(x-2\right)\left(x_{2}-4\right)}
Do the multiplications in x\left(x_{2}-4\right)-8\left(x-2\right).
\frac{xx_{2}-12x+16}{\left(x-2\right)\left(x_{2}-4\right)}
Combine like terms in xx_{2}-4x-8x+16.
\frac{xx_{2}-12x+16}{xx_{2}-4x-2x_{2}+8}
Expand \left(x-2\right)\left(x_{2}-4\right).