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Differentiate w.r.t. x
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\frac{\mathrm{d}}{\mathrm{d}x}(\frac{8y^{5}z^{5}}{2y_{3}z^{5}}x^{3-2})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}x}(\frac{4y^{5}}{y_{3}}x^{1})
Do the arithmetic.
\frac{4y^{5}}{y_{3}}x^{1-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
\frac{4y^{5}}{y_{3}}x^{0}
Do the arithmetic.
\frac{4y^{5}}{y_{3}}\times 1
For any term t except 0, t^{0}=1.
\frac{4y^{5}}{y_{3}}
For any term t, t\times 1=t and 1t=t.
\frac{4xy^{5}}{y_{3}}
Cancel out 2x^{2}z^{5} in both numerator and denominator.