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Differentiate w.r.t. x
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\frac{8\times 0.125}{x^{2}+4\times 0.5^{2}}
Calculate 0.5 to the power of 3 and get 0.125.
\frac{1}{x^{2}+4\times 0.5^{2}}
Multiply 8 and 0.125 to get 1.
\frac{1}{x^{2}+4\times 0.25}
Calculate 0.5 to the power of 2 and get 0.25.
\frac{1}{x^{2}+1}
Multiply 4 and 0.25 to get 1.
\frac{\mathrm{d}}{\mathrm{d}x}(\frac{8\times 0.125}{x^{2}+4\times 0.5^{2}})
Calculate 0.5 to the power of 3 and get 0.125.
\frac{\mathrm{d}}{\mathrm{d}x}(\frac{1}{x^{2}+4\times 0.5^{2}})
Multiply 8 and 0.125 to get 1.
\frac{\mathrm{d}}{\mathrm{d}x}(\frac{1}{x^{2}+4\times 0.25})
Calculate 0.5 to the power of 2 and get 0.25.
\frac{\mathrm{d}}{\mathrm{d}x}(\frac{1}{x^{2}+1})
Multiply 4 and 0.25 to get 1.
-\left(x^{2}+1\right)^{-1-1}\frac{\mathrm{d}}{\mathrm{d}x}(x^{2}+1)
If F is the composition of two differentiable functions f\left(u\right) and u=g\left(x\right), that is, if F\left(x\right)=f\left(g\left(x\right)\right), then the derivative of F is the derivative of f with respect to u times the derivative of g with respect to x, that is, \frac{\mathrm{d}}{\mathrm{d}x}(F)\left(x\right)=\frac{\mathrm{d}}{\mathrm{d}x}(f)\left(g\left(x\right)\right)\frac{\mathrm{d}}{\mathrm{d}x}(g)\left(x\right).
-\left(x^{2}+1\right)^{-2}\times 2x^{2-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
-2x^{1}\left(x^{2}+1\right)^{-2}
Simplify.
-2x\left(x^{2}+1\right)^{-2}
For any term t, t^{1}=t.