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Differentiate w.r.t. x
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\frac{\mathrm{d}}{\mathrm{d}x}(\frac{48\sqrt[6]{x}}{18\sqrt[3]{x}}x^{\frac{2}{3}-\frac{5}{12}})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}x}(\frac{8}{3\sqrt[6]{x}}\sqrt[4]{x})
Do the arithmetic.
\frac{1}{4}\times \frac{8}{3\sqrt[6]{x}}x^{\frac{1}{4}-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
\frac{2}{3\sqrt[6]{x}}x^{-\frac{3}{4}}
Do the arithmetic.