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Differentiate w.r.t. b
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\frac{4a^{4}b^{4}c^{6}\times 64b^{3}}{4096a^{4}b^{8}c^{12}}
To multiply powers of the same base, add their exponents. Add 2 and 2 to get 4.
\frac{4a^{4}b^{7}c^{6}\times 64}{4096a^{4}b^{8}c^{12}}
To multiply powers of the same base, add their exponents. Add 4 and 3 to get 7.
\frac{1}{16bc^{6}}
Cancel out 4\times 64a^{4}c^{6}b^{7} in both numerator and denominator.